Lawsonia and SODC gene derived from related polypeptides, peptides and Proteins, and their uses

摘要

Refers to an isolated or recombinant immunogenic polypeptide that mimics, reacts with a B Cell or T cell epitope of a polypeptide capable of achieving the production of Antibodies,Confer a protective immune response against Lawsonia spp SODC Lawsonia intracellularis when administered as a Bird, Pig, is selected from: (a) a Peptide, oligopeptide,Polypeptide comprising an Amino Acid Sequence that has at least 70% Sequence identity with the Amino Acid Sequence in the SEC ID no: 1, or the amino acid sequence of CODIIfied by the Nucleotide sequence encoding the SODC of palk13 (ATCC 207196) was essentially the coding sequence of the palk14 (ATCC 207155); (b) a Peptide, oligopeptide,Polypeptide comprising an Amino Acid Sequence that is at least 50% identity with the sequence of residues 1 to 42 sec id no: 1; (c) a homolog, AnalogDerivative that mimics a B Cell or T cell epitope of a polypeptide of Lawsonia spp SODC.Also refers to a vaccine that also includes a Second immunogenic component that comprises an antigenic Peptide, polypeptide, Protein L.Intracellularis as DPI, flge, hemolysin, autolisina; Vaccine Vector for an isolated Molecule, Nucleic Acid, palk14 Plasmid