Pyrethroids and polycyclic heteromorphic substitutes for selective inhibition of coagulation cascade

摘要

IT REFERS TO SUBSTITUTED PYRIMIDONES OF ARMS AND POLYCYCLIC HETEROARILS OF FORMULA I, WHERE: B IS A GROUP b; R9-R13, R32-R36 ARE ACETAMIDE, HALOACETAMIDE, AMONG OTHERS; R9-R13 ARE HETEROARYL, HETERO CYCLYLE IF R9-R13 ARE NOT SUBSTITUTES FOR B; R16, R19, R32-R36 ARE Qb, ONE OF R16 AND R19 IS Qb AND Qb IS Qbe; B IS TRIALCHYLSILYL, ALKYL C2-C8, AMONG OTHERS; A IS A LINK, (W7) rr- (CH (R15)) pa, AMONG OTHERS; rr is 0-1; pa ES 0-6; W7 IS O, S, C (O),(R7) NC (O)AMONG OTHERS; R7 IS OH, ALKYL; R15 IS OH, HALO, ALKYL, HALOALKYL; ES NH, NOH; M ES N, R1-C; R1 IS RENT, CIANO, AMONG OTHERS; R2 ES Z ° -Q; Z ° ES (CR41R42) q; q IS 1-3; R41 AND R42 ARE AMIDINE, HYDROXYAMINE, AMONG OTHERS; Q IS A GROUP II; D1, D2, J1, J2, K1 ARE C, N, O, S, ONE LINK; K ES (CR4aRb) n; n IS 1-2; R4a AND R4b ARE HALO, HYDROXIALKYL, ALKYL; E ° ES E1; E1 IS CO, CS, CONR7, SO2, AMONG OTHERS; AND ° IS GROUP IV, AMONG OTHERS; D5, D6, J5, J6 ARE C, N, O, S, AMONG OTHERS; Qb IS AMINO ALKYLENYL, AMONG OTHERS; Qbe IS NR6CNR25NR23R24, AMONG OTHERS. NO MORE THAN ONE OF R20 AND R21 or R23 AND R24 ARE OH, AMINO, AMONG OTHERS; R20 TO R26 ARE RENT, OH,There are others The alternative pyridine compounds are SERINA protein inhibitors in the coagulation cascade, so they can be used in the treatment of thrombus, coronary artery and cerebrovascular diseases.