1. Fungi related to multidrug resistance (MRP-1) as protein-1 inhibitors and their derivatives

摘要

It refers to the use of toxins such as vinblastine, vinristina, vincertina, vincerticina, vincena, vinorelbina, daunorobicina, doxorubicina, mitroxantrona, etoposido, teposido, microcomicina C, actinomicina D, tasol, topotecan, mitramizina, colquicina, puromisina, podoofilo, bromuro de etio, emetina, gramicina D, valinomina and a compound. Formula 1: R is h; R1 is group A; R4 is oh, alcoxi C1-C6, nr5r6; R5 is h, C1-C6 tar, benzene; R6 is h, C1-C6 tar, aralquilo, etc.; R and R ` form a different group B excimer, among others; or they form a double-layer link or an epoxy with C; R1 is f and R2; Oh R1 isEster and R2 are Oh, fluoro, cloro, nr7r8, xr9; R7 is h, C1-C6 asphalt, benzene; R8 is h, C1-C6 asphalt, C3-C7 cyclopropyl compound, etc.; or R7 and R8 and N component isomers piperidina, pirrolidina, morfolin, etc.; X is O, s; R9 is C1-C6 asphalt, C3-C7 cyclopropene, etc.; c13-c6, etc. Compound I inhibits resistance to a variety of drugs by improving the effectiveness of chemotherapy against cancer and malaria