PROCESS FOR THE PREPARATION OF BACCATIN III AND 10-DEACETYL BACCATIN III DERIVATIVES

摘要

A process for preparing taxane derivatives of formula (I) wherein R 1 is acetyl or a protecting group, G 1 is a protecting group and R is a tert-butoxy or phenyl group, wherein the starting compound of formula (VI) wherein R 1 is R 1 and G 1 are as defined above and R 2 is a hydroxyl protecting group selected from methoxymethyl, 1-ethoxyethyl, benzyloxymethyl, (beta-trimethylsilylethoxy) methyl or tetrahydropyranyl;