CTLA4 IG fusion protein to regulate Cellular interactions and immune responses.

摘要

As a ligand for the receptor CTLA4 Antigen B7. Provides the complete amino acid sequence of Human CTLA4 encodes The receptor gene.Methods are provided for expressing a fusion protein of CTLA4 and immunoglobulin fusion protein to prepare to use Hybrid CTLA4 and soluble fusion proteins.Fragments and Derivatives thereof, including Monoclonal Antibodies that REACT with B7 and CTLA4,For regular Interactions with T cells and immune responses mediated by these interactions.Claims: 1) ctla4ig fusion protein that binds to the Antigen B7Taking the first amino acid sequence of a Protein consisting of the extracellular domain of CTLA4 and a Second Amino Acid Sequence that consists of the axisThe CH2 and CH3 regions of the Molecule of a human immunoglobulin.2) a ctla4ig fusion protein that binds to the Antigen B7(a) a Protein having the Amino Acid Sequence that starts with the first amino acid alanine at position 1 and ending with the Aspartic acid at amino acid position of the 125 SEQ id no: 13 represents the CTLA4 extracellular domain and (b) a Second Amino Acid Sequence that consists of the Axis, and the CH2 and CH3 regions of a Molecule of human immunoglobulin.