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FUSION AND HYBRID FUSION PROTEINS FOR REGULATING CTLA4 POSITIVE T-CELL INTERACTIONS WITH B7 POSITIVE CELLS AND IMMUNE RESPONSES
FUSION AND HYBRID FUSION PROTEINS FOR REGULATING CTLA4 POSITIVE T-CELL INTERACTIONS WITH B7 POSITIVE CELLS AND IMMUNE RESPONSES
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机译:用于调节CTLA4阳性T细胞与B7阳性细胞相互作用和免疫反应的融合和混合融合蛋白
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摘要
The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
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