method for the separation and quantification of two designs of beta2 microglobulin in dynamic balance

摘要

The present patent refers to a method for the separation and quantification of physiologically relevant isoforms of beta2 microglobulin, in particular of the native form and of its amyloidogenic form, carried out by capillary electrophoresis under temperature-controlled conditions. This separation method faithfully reflects the existing ratios between the said isoforms in physiological solutions, buffers of ionic strength and pH corresponding to these of plasma, serum and urine and allow a precise evaluation of the concentrations present in the samples subjected to analysis.