Reagents and procedures quantification of all the doxepinas in biological fluids.

摘要

They ARE PRESENTED immunoassay methods and reagents for quantification DOXEPINAS TOTAL (FOR EXAMPLE DOXEPIN E, doxepin Z, DESMETILDOXEOPINA desmethyldoxepin EY) in a test sample. Quantification of DOXEPINAS is performed in an immunoassay employing antibodies prepared DERIVATIVES OF DOXEPINAS FORMULA (II) WHERE YZ COULD BE C = CO N-CH2, R1 a linking group, R2 BE HO CH3 YQ MAY BE A detectable unit CARRIER MATERIAL OR immunogenic. Antibody reagent comprising antibodies which are capable of binding to TOTAL DOXEPINAS and are produced with one or more immunogens PREPARATIONS OF DERIVATIVE doxepin of formula (II) and the reagent of formula (II) and the labeling reagent PREPARES Also from dOXEPIN derivative of formula (II)