TREATMENT, DIAGNOSIS AND EVALUATION OF ANTI-CANCER THERAPY RESISTANCE IN MELANOMA

摘要

The invention relates to overcoming anti-cancer therapy resistance in melanomaby regulation of the expression of tyrosinase related protein 2 (TYRP2).Treatment ofmelanoma with anti-cancer therapy may be negatively impacted by anti-cancerresistance ofmelanoma cells. Altering expression of TYRP2 in melanoma cells can enhanceefficacy ofanti-cancer therapies, such as chemotherapy and radiotherapy. The use of aTYRP2reducer, ase well as methods for treatment of melanoma are disclosed. Further,methodsfor diagnosis of anti-cancer therapy resistance, and methods for evaluatingcandidateanti-cancer therapies for melanoma. Down-regulation of TYRP2 expression oractivity can beaccomplished using a genetic therapy such as antisense therapy, or by usingsmallmolecules which regulate TYRP2.