COMPOSITIONS AND METHODS FOR INCREASING CHOLESTEROL EFFLUX AND RAISING HDL USING ATP BINDING CASSETTE TRANSPORTER PROTEIN ABCI

摘要

The present invention relates to novel ABC1 polypeptides and nucleic acidmolecules encoding the same. The invention also relates to recombinantvectors, host cells, and compositions comprising ABC1 polynucleotides, as wellas to methods for producing ABC1 polypeptides. The invention also relates toantibodies that bind specifically to ABC1 polypeptides. In addition, theinvention relates to methods for increasing cholesterol efflux as well as tomethods for increasing ABC1 expression and activity. The present inventionfurther relates to methods for identifying compounds that modulate theexpression of ABC1 and methods for detecting the comparative level of ABC1polypeptides and polynucleotides in a mammalian subject. The present inventionalso provides kits and compositions suitable for screening compounds todetermine the ABC1 expression modulating activity of the compound, as well askits and compositions suitable to determine whether a compound modulates ABC1-dependent cholesterol efflux.