CONTROLLING OFFSPRING'S SEX RATIO BY TARGETING TRANSGENES ONTO THE SEX CHROMOSOMES

摘要

A method for controlling the sex ratio of offspring by targeting transgenes.The method involves: (a) selecting or creating a transgene whose expressioncan interfere with sperm's ability to undergo fertilization, and whose geneproducts (mRNA and protein) do not diffuse freely among inter-connectedspermatids; (b) placing the transgene under the regulatory control of post-meiotic spermatogenesis-specific promoter; and (c) using the transgene togenerate transgenic animals in the way that the transgene is inserted onto oneof the two sex chromosomes.