A kind of control sex ratio alteration in offspring is by targeting metastatic gene. This method is related to: (one) selection generates a kind of transgenosis, whose expression may with the ability of sperm with apply fertilizer, whose gene product (mRNA and albumen) cannot the free disperse in the spermatoblast of interconnection; (2) specific promoter of the transgenosis in regulatory control postmeiotic spermatogenesis is placed; (3) transgenic animals are generated using the transgenosis to get in the way on the sex chromosome that this transgenosis is inserted in two.
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