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Identification of LTiGTcandida albicansLT/iGT essential fungal specific genes and use thereof in antifungal drug discovery
Identification of LTiGTcandida albicansLT/iGT essential fungal specific genes and use thereof in antifungal drug discovery
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机译:LTiGT白色念珠菌LT / iGT必需真菌特异性基因的鉴定及其在抗真菌药物发现中的用途
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摘要
The invention relates to the identification and disruption of essential fungal specific genes isolated in the yeast pathogen Candida albicans namely CaKRE5, CaALR1, and CaCDC24 and to the use thereof in antifungal diagnosis and as essential antifungal targets in a fungal species for antifungal drug discovery. More specifically, the invention relates to the CaKRE5, CaALR1, and CaCDC24 genes, to their use to screen for antifungal compounds and to the drugs identified by such.
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