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FOLYLPOLYGLUTAMYL SYNTHETASE GENE TRANSFER TO ENHANCE ANTIFOLATE DRUG SENSITIVITY
FOLYLPOLYGLUTAMYL SYNTHETASE GENE TRANSFER TO ENHANCE ANTIFOLATE DRUG SENSITIVITY
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机译:羟丙基谷氨酰胺合成酶基因转移增强抗药性
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摘要
Methods of killing neoplastic cells are provided. The invention relates to the use of folylpolyglutamyl synthetase (FPGS) gene transfer to enhance the sensitivity of several types of tumor cells to polyglutamylatable antifolate drugs, such as methotrexate (MTX) and edatrexate (EDX).
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