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PROCESS FOR INDUCING IMMUNOLOGICAL TOLERANCE FOR XENOGENEIC TRANSPLANTS
PROCESS FOR INDUCING IMMUNOLOGICAL TOLERANCE FOR XENOGENEIC TRANSPLANTS
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机译:异种移植的免疫耐受性诱导过程
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摘要
The present invention relates to methods of inducing immunological tolerance in an animal receiving xenogeneic cells and tissues, especially by way of transplant, said methods comprising myeloablative or non-myeloablative conditioning regimens and administration to the recipient of a therapeutically effective amount of a mixture of transforming growth factor-β (TGF-β) antagonists and tumor necrosis factor-α (TNF-α) antagonists. The methods also include the use of anti-T cell antibodies as well as co-stimulatory blockade molecules such as anti-CD40 Ligand antibody and CTLA4lg.
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