DEVICE FOR DETERMINING CEREBRAL BLOOD FLOW AND INTRACEREBRAL BLOOD VOLUME

摘要

A process and device are disclosed for determining cerebral blood flow and intracerebral blood volume. After a predetermined amount of a double indicator is injected into the blood stream, dilution curves that result from the dilution of indicator in the blood stream are measured in arteries and veins and plotted. A dye solution with a temperature that differs from the body temperature is used as double indicator. Heat or cold forms a highly diffusible indicator component and the dye, preferably indocyanine green (ICG), forms an intravascular indicator component. The cerebral blood flow (CBF) is calculated from the quotient of a distribution coefficient μtherm of the highly diffusible indicator component (Therm) between blood and cerebral tissues multiplied by the means transit time mtttherm of the higly diffusible indicator component (Therm) through the brain. The intracerebral blood volume (ICVB) is calculated from the product of cerebral blood flow (BCF) by the mean transit time mttICG of the intravascular indicator component (ICG).