AIDS DNA VACCINE INDUCING PROTECTION AGAINST SIVMAC239 INFECTIONS FROM MONKEY

摘要

PURPOSE: A plasmid for DNA vaccine containing a gene generated from simian immunodeficincy virus is provided, which can be effectively used for the treatment as well as prevention of AIDS caused by HIV infections by exhibiting excellent efficacy in an animal model have never been succeed in a DNA vaccine for the prevention of AIDS. CONSTITUTION: A DNA vaccine contains plasmid pSIV/pol containing a pol gene generated from pSIV/GE which contains gag, dpol, env and rev gene of SIV but does not contain tat, nef, and plasmid pSIV/pol containing a pol gene from SIV; plasmid pSIV/GE and pHIV/pol obtained by substituting a corresponding gene generated from HIV for a gene from SIV in pSIV/GE and pSIV/pol; and pHIV/GE and pHIV/pol.