Manufacturing and synergic effect of topical anesthetic formula consisted of mixed local anesthetics

摘要

PURPOSE: Provided is a topical anesthesia formulated in the form of liposome and having transdermal effect good enough for the clinical application, thereby expressing shortly and retaining long its action. CONSTITUTION: The topical anesthesia is formulated as liposome preparation by mixing 0.5-20 wt.% of topical anesthesia, such as lidocaine, tetracaine, ropivacaine, cocaine and the like; and phospholipid, such as phosphatidylcholine, lecithin, phosphatidyldioleoyl, phosphatidylpalmitoyl, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, polyoxyethylene and the like, and cholesterol as a matrix.