DERIVATIVES OF TETRAFURAZANO-3,4-B:3',4'-F:3'',4''-J:3''',- -4'''-N-1,4,5,8,9,12,13,16-OCTAAZABICYCLO-14,2,2-EICOSA- -4,8,12-TRIENE AND METHOD OF THEIR SYNTHESIS

摘要

FIELD: organic chemistry of heterocyclic compounds, chemical technology. SUBSTANCE: invention relates to novel class of chemical compounds, namely to derivatives of the novel heterocyclic system tetrafurazano-[3,4-b: 3', 4'-f: 3'', 4''-j: 3''', 4'''-n] - -[1,4,5,8,9,12,13,16]-octaazabicyclo-[14.2.2]-eicosa-4,8,12- -triene of the general formula (I) where R₁, R₂, R₃, R₄ are H, lower alkyl or lower alkyl containing functional groups, for example, OR₅, SR₅, NR₅R₆, CONR₅R₆ or COOR₇ where R₅, R₆, R₇ are H, lower alkyl, or R₂ + R₃ and/or R₁ + R₄ in common with adjacent carbon atoms of piperizine cycle form alicyclic, benzene or heterocyclic annealed cycle. Invention describes also method of their synthesis involving treatment of derivatives of bis-1,4-(3-aminofurasanyl-4,4'-azofurazan-3-yl)-piperazine with dibromoisocyanourate in medium of trifluoroacetic acid or its mixture with inert organic solvents, for example, CH₂Cl₂, CHCl₃, CH₃CN. Synthesized compounds can be used in biochemistry in investigation of regulatory effects of nitrogen oxide and mechanism of action of soluble form of guanylate cyclase. EFFECT: new compounds indicated above, improved method of synthesis. 3 cl, 8 ex