Method of production of alpha-amino acids for use in peptide synthesis

摘要

An alpha -amino acid amide is prepared by reacting an N alpha -aryloxycarbonyl amino acid with a compound containing a free amino group. This process makes it possible to easily prepare peptides by direct reaction between the carboxyl group of the N alpha -aryloxycarbonyl derivative of an amino acid and the free amino group of a second amino acid or of a peptide fragment without any need to protect the carboxyl functional group of the second amino acid or of the peptide fragment, nor for a coupling agent or a deprotection step.