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Method for identifying suppressor mutations for common p53 cancer mutations
Method for identifying suppressor mutations for common p53 cancer mutations
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机译:鉴定常见p53癌症突变的抑制突变的方法
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摘要
Intragenic suppressor mutations of common p53 mutations are able to function in cis and/or trans. These mutations are useful for identifying small molecule drugs which function in a similar fashion. In addition, the mutations themselves may be useful therapeutically, especially if they function in trans. Methods for rapidly obtaining this type of mutant employ a yeast selection system. Cells having both the negative mutation and intragenic suppressor are useful for studying the interactions of the two, in particular in determining the structure of the homotetramers and heterotetramers.
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