Use of (BMP) receptor complex bone morphogenetic protein for the screening

摘要

(57) for the screening of cell differentiation activity, [summary] The present invention relates to the use of bone morphogenetic protein type II receptor, along with the type I receptor, the type II receptor bone morphogenesis and activin I is located between the protein. The present invention relates to the DNA-containing cells and DNA encoding the receptor. The present invention relates to a method for measuring and test compound, whether it is possible that the compound binds to a novel BMP complex whether to generate a signal for binding to BMP receptor protein complex. The present invention relates to a method of addition, using a novel BMP complex, measuring the concentration of BMP receptor ligand in a clinical sample. The present invention still further, the present invention relates to host cells that this complex were co-expressed with an expression vector comprising a DNA sequence or encoding a component of the soluble fragment.