OPTICALLY ACTIVE QUATERNARY AMMONIUM SALT HAVING AXIAL ASYMMETRY AND STEREOSELECTIVE SYNTHESIS OF - HYDROXYKETONE USING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide an optically active quaternary ammonium fluoride having axial asymmetry, and further to provide a method for stereospecifically synthesizing a -hydroxyketone by using the quaternary ammonium fluoride which has been formed by reacting a corresponding bisulfate with potassium fluoride directly to an aldol reaction (a reaction of a carbonyl compound with a silyl enol ether) without separating it from the reaction mixture.;SOLUTION: A -hydroxyketone specifically having stereoselectivity is obtained by reacting a compound expressed by the formula (III) with an alkali metal fluoride and subsequently reacting a carbonyl compound with silyl enol ether in the presence of the reaction product obtained by the above reaction.;COPYRIGHT: (C)2002,JPO