SOLID PREPARATION INCLUDING HYDROXYPROPYL CELLULOSE OF LOW SUBSTITUTION DEGREE AND METHOD FOR PREPARATION OF THE SAME

摘要

PROBLEM TO BE SOLVED: To provide a solid preparation quickly collapsing in the oral cavity by saliva in the oral cavity or taking with a small amount of water, easy to prepare, having a proper strength capable of retaining its molding property in preparation and in distribution process. SOLUTION: This solid preparation includes a hydroxypropyl cellulose of low substitution degree having volume average particle size =25 m measured by a dry laser diffraction method, bulk density of 0.35 g/mL in loosely packed state and 0.60 g/mL of bulk density in a tightly packed state and a sugar/sugar alcohol, and its preparative method.