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INHIBITION OF THROMBIN-INDUCED PLATELET AGGREGATION BY CREATINE KINASE INHIBITORS
INHIBITION OF THROMBIN-INDUCED PLATELET AGGREGATION BY CREATINE KINASE INHIBITORS
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机译:酪氨酸激酶抑制剂抑制凝血酶诱导的血小板凝集
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摘要
Methods of using creatine compounds such as creatine kinase inhibitors, and more particularly, cyclocreatine and homocyclocreatine, to inhibit thrombin-induced cytoskeletal reorganization, platelet aggregation, inflammatory processes, endothelial cell contraction and related cardiovascular and CNS disorders are described. ;Pharmaceutically effective amounts of creatine compounds are administered to subjects in need thereof to thereby prevent and/or treat diseases and/or pathological conditions such as thrombosis, thrombocytopenia, atherosclerosis, coronary artery disease, unstable angina pectoris, myocardial infarction, stroke, coagulopathies, and transient ischemia attacks.
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