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Inhibition of thrombin-induced platelet aggregation by creatine kinase inhibitors
Inhibition of thrombin-induced platelet aggregation by creatine kinase inhibitors
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机译:肌酸激酶抑制剂抑制凝血酶诱导的血小板凝集
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摘要
Methods of using creatine compounds such as creatine kinase inhibitors, and more particularly, cyclocreatine and homocyclocreatine, to inhibit thrombin-induced cytoskeletal reorganization, platelet aggregation, inflammatory processes, endothelial cell contraction and related cardiovascular and CNS disorders are described. Pharmaceutically effective amounts of creatine compounds are administered to subjects in need thereof to thereby prevent and/or treat diseases and/or pathological conditions such as thrombosis, thrombocytopenia, atherosclerosis, coronary artery disease, unstable angina pectoris, myocardial infarction, stroke, coagulopathies, and transient ischemia attacks.
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