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Supplementing engineered annulus tissues with autograft or allograft tendons

机译:用自体或同种异体肌腱补充工程化的环组织

摘要

Fibrocytes, annulus fibrosis cells, cells that differentiate into annulus fibrosis cells, or cells that function like annulus fibrosis cells are harvested and combined with the extracellular matrix of the annulus fibrosis from a recently deceased human or animal to produce an engineered annulus fibrosis. Autograft tendons are then used to strengthen the annulus fibrosis and to augment or replace the nucleus pulpous. In accordance with a preferred embodiment, tendons such as the palmaris longus are harvested from the patient, a suitable living donor, or a recently deceased human. The tendons are sewn or otherwise attached to the inside of the annulus fibrosis using percutaneous or laparoscopic procedures. The tendons aid the nucleus and/or replace the nucleus by absorbing the compression forces between vertebrae and by transferring the compression forces to the augmented annulus fibrosis. Allograft tendons are preferably treated, with tissue banking techniques well known to those skilled in the art, to prevent disease transmission and graft rejection. The invention can be used to augment discs in the cervical, thoracic, or lumbar spine.
机译:收集纤维细胞,纤维环纤维化细胞,分化为纤维环纤维化细胞的细胞或功能类似于纤维环纤维化细胞的细胞,并将其与最近去世的人或动物的纤维环纤维化的细胞外基质组合,以产生工程化纤维环纤维化。然后使用自体移植肌腱强化环纤维化并增强或置换髓核。根据优选的实施方案,从患者,合适的活体供体或新近去世的人中收获肌腱例如长掌。使用经皮或腹腔镜手术将肌腱缝合或以其他方式附着到纤维环的内部。肌腱通过吸收椎骨之间的压缩力并将压缩力传递到增强的环形纤维化上,从而辅助细胞核和/或替换细胞核。优选用本领域技术人员众所周知的组织库技术处理同种异体移植肌腱,以防止疾病传播和移植排斥。本发明可用于增强颈椎,胸椎或腰椎中的椎间盘。

著录项

  • 公开/公告号US2002156532A1

    专利类型

  • 公开/公告日2002-10-24

    原文格式PDF

  • 申请/专利权人 FERREE BRET A.;

    申请/专利号US20020167503

  • 发明设计人 BRET A. FERREE;

    申请日2002-06-13

  • 分类号A61F2/44;

  • 国家 US

  • 入库时间 2022-08-22 00:52:07

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