DSP-14 dual-specificity phosphatase

摘要

Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-14, and polypeptide variants thereof that stimulate dephosphorylation of DSP-14 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-14 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.