首页> 外国专利> Method of attenuating pathogenic mycobacteria and strains of mycobacteria so attenuated

Method of attenuating pathogenic mycobacteria and strains of mycobacteria so attenuated

机译：减轻致病性分枝杆菌的方法和如此减弱的分枝杆菌菌株

页面导航

摘要
著录项
相似文献

摘要

This invention provides for novel attenuated strains of Mycobacterium tuberculosis and M. bovis. Attenuation is achieved by eliminating or by downregulating the expression of the &agr;-crystallin heat shock protein gene (“acr gene”). The invention provides for vaccines and methods of vaccinating mammals for protection against Mycobacterium sp. that cause tuberculosis.

机译：本发明提供了新的结核分枝杆菌和 M的减毒株。牛通过消除或下调α-结晶蛋白热激蛋白基因（“ acr基因”）的表达来实现衰减。本发明提供疫苗和疫苗接种方法以保护哺乳动物免受分枝杆菌sp。导致结核病。 展开▼

著录项

公开/公告号US6403100B1

专利类型

公开/公告日2002-06-11

原文格式PDF

申请/专利权人 THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES;
展开▼

申请/专利号US20000462556

发明设计人 CLIFTON E. BARRY III;DEBORAH D. CRANE;YING YUAN;
展开▼

申请日2000-06-27

分类号A61K390/40;A61K490/00;C12N150/00;C12N157/40;C12N10/00;

国家 US

入库时间 2022-08-22 00:49:07

相似文献

专利

外文文献

中文文献

1. 包含新型温度敏感性分枝杆菌菌株的对分枝杆菌感染症的疫苗组合物 [P] . 中国专利： CN106794201A . 2017-05-31

2. 可表达结核分枝杆菌Ag85B和ESAT-6融合蛋白的重组耻垢分枝杆菌株及其应用 [P] . 中国专利： CN101875913B . 2012.05.23

3. METHOD OF ATTENUATING PATHOGENIC MYCOBACTERIA AND STRAINS OF MYCOBACTERIA SO ATTENUATED [P] . 欧洲知识产权局专利： EP0994944A1 . 2000-04-26

机译：减轻致病性分枝杆菌的方法和如此减弱的分枝杆菌菌株

4. METHOD OF ATTENUATING PATHOGENIC MYCOBACTERIA AND STRAINS OF MYCOBACTERIA SO ATTENUATED [P] . 世界知识产权组织专利： WO9902670A1 . 1999-01-21

机译：减轻致病性分枝杆菌的方法和如此减弱的分枝杆菌菌株

5. Method of attenuating pathogenic mycobacteria and strains of mycobacteria so attenuated [P] . AU8296498A . 1999-02-08

机译：减轻致病性分枝杆菌的方法和如此减弱的分枝杆菌菌株

1. Effect of Attenuated Highly Pathogenic Pig Reproductive and Respiratory Syndrome(HP-PRRS) TJM-F92 Strain Vaccine on Immune Antibody Levels against Classical Swine Fever(CSF) and Foot-and-Mouth Disease(FMD) [J] . Luo Zhizhong, Fu Xiandong, Wang Yan 动物与饲料科学：英文版 . 2016,第003期

2. Effect of Attenuated Highly Pathogenic Pig Reproductive and Respiratory Syndrome（HP-PRRS） TJM-F92 Strain Vaccine on Immune Antibody Levels against Classical Swine Fever（CSF） and Foot-and-Mouth Disease（FMD） [J] . Luo Zhizhong, Fu Xiandong, Wang Yan 动物与饲料科学：英文版 . 2016,第003期

3. Evaluating the efficacy of an attenuated Streptococcus equi ssp.zooepidemicus vaccine produced by multi-gene deletion in pathogenicity island SeseCisland_4 [J] . MA Fang, WANG Guang-yu, ZHOU Hong, 农业科学学报（英文版） . 2019,第005期

4. Evaluating the efficacy of an attenuated Streptococcus equi ssp. zooepidemicus vaccine produced by multi-gene deletion in pathogenicity island SeseCisland4 [J] . MA Fang, WANG Guang-yu, ZHOU Hong, 农业科学学报：英文版 . 2019,第005期

5. A comprehensive study for mass attenuation coefficients of different parts of the human body through Monte Carlo methods [J] . E.E.Ermis, F.B.Pilicer, E.Pilicer, 核技术（英文版） . 2016,第003期

6. Utilizing Negative Markers for Identifying Mycobacteria Species based on Mass Spectrometry with Machine Learning Methods [C] . Jongseo Lee, Kyoohyoung Rho, Kyu H. Park, IEEE International Conference on Bioinformatics and Biomedicine . 2019

7. Characterizing the differential response by primary macrophages to infection by pathogenic and non-pathogenic mycobacteria. [D] . Yadav, Mahesh. 2006

8. Comparative Proteomic Profiling of Ehrlichia ruminantium Pathogenic Strain and Its High-Passaged Attenuated Strain Reveals Virulence and Attenuation-Associated Proteins [O] . Marcelino Isabel, Ventosa Miguel, Pires Elisabete, 2010

9. Comparative proteomic profiling of Ehrlichia ruminantium pathogenic strain and its high-passaged attenuated Strain reveals virulence and attenuation-associated proteins [O] . Marcelino, Isabel, Ventosa, Miguel, Pires, Elisabete, 2015

1. 四种重要致病性分枝杆菌DHPLC检测鉴别方法的建立 [C] . 陈茹 ,刘志玲 ,刘志辉 . 中国畜牧兽医学会2009学术年会 . 2009

2. 结核分枝杆菌北京基因型菌株的鉴定及分型方法的建立及应用 [A] . 陈婧 . 2009