Radiolabeled 1-aryl pyrazoles, the synthesis thereof and the use thereof as pest GABA receptor ligands

摘要

The present invention is directed to radiolabeled compounds of Formula I: ;or salts thereof, where;R¹ represents R⁸, R⁸O, R⁸SO₂, R⁸SO or R⁸S in which R⁸ is tritiated or deuterated methyl;;X is halo, cyano, C_1-6 alkoxycarbonyl, C_2-6 alkynyl, optionally substituted;C_6-14 aryl or an optionally substituted 5- to 7-membered heteroaromatic ring linked to thiazole via a carbon-carbon bond;;R² is hydrogen or amino; and;R³-R⁷ are defined in the specification.;The invention is also directed to methods of using such compounds for demonstrating specific insect GABA receptors, qualitatively screening for compounds acting on an insect GABA receptor or quantitatively assaying concentrations of a compound acting on an insect GABA receptor.