Method for determining ancestral haplotypes using haplospecific geometric elements within the major histocompatibility complex multigene cluster

摘要

The present invention relates to haplotype-specific genomic elements (HGEs) present in multigene complexes of higher organisms. The present invention provides the genetic characterizations of the HGEs for the human Major Histocompatibility Complex. The present invention further relates to a method of determining the ancestral haplotypes of higher organisms by using approaches based on HGEs. The method of the present invention can be applied to distinguish haplotypic differences in genes of multigene complex, such as MHC genes, which is very useful in clinical applications.