Compounds of 7 - (benzo (b) thiophene, Furan and indolpiridil or tetrahidropiridilo), effective on systems related to serotonin.Composicionesfarmaceuticas made with such Compounds; Compounds, Intermediates useful for preparing such compounds thiophene, Furan and indolpiridilo otetr

摘要

These compounds of formula I are useful to inhibit the uptake of serotonin, antagonize the 5-ht1a receptor and antagonize the 5-ht2a receptor.Through the management of people Refer to such treatment, characterized porquecantidade s effective of a compound of formula I in which X I, S, NR, S (= o) or s (= o) 2; and - C (= o) -,CH (OH) -, - C (= CH2, NOR), chnr7r, S, so or SO2; = represents a simple link or double; n is 1, 2, 3 or 4; R is H oalquilo C1 - 6; each A1A, r1b, r1c and R 2 is Regardless, h, F, CL, BR, I,Oh, alkyl C1 C1 - 6, 6 - alkoxy alkyl, Halo Alquiltio C1 C1 - 6, 6 -, phenyl -, NO2, nr7r8, - C (= o) - nr78r8, R8, nr7c (= o)CN or phenyl substituted with 1 to 3 substituents selected from the group composed of F, CL, b r, I, Oh, alquiloc1 C1 - 6, 6 - alkoxy alkyl, Halo Alquiltio C1 C1 - 6, 6 -, phenyl, NO2 or CN, NH2; R3 is H,Oh, alkyl hydroxy - C1 - 6, 6 - alkoxy alkyl C1, C1 and C1 - 6 - 6 Alquiltio; R4 esarilo, Heterocyclic cycloalkyl, aryl substituted C3 - 8 s 1 A3 Substituent selected from the group consisting of F,CL, BR, I, Oh, alkyl alkoxy C1 C1 - 6, - 6, - 6 Alquiltio haloalquilo C1, C1 - 6, phenyl, or cn or NO2, NH2; heterocycle substituted with 1 to 3 substituents selected from the grupocompuestopor F, CL, BR,I, Oh, alkyl C1 C1 - 6, 6 - alkoxy alkyl, Halo Alquiltio C1 C1 - 6, 6 -, phenyl, NO2 or CN, NH2; R5 is aryl, Heterocyclic cycloalkyl, c3-6,Arilosustituido with 1 to 3 substituents selected from the group consisting of F, CL, BR, I, Oh, I lcoxi C1 C1 - 6, - 6, 6 - hydroxy alkyl C1, C1 - 6 Halo alkyl, phenyl, NO2,NH2 or ns; or heterocycle substituted with 1 to 3 substituents selected from the group consisting of F, CL, BR, I, o, alquiloc1 - 6, 6 - alkoxy C1, C1 - 6 Hydroxy alkyl, phenyl, Alquiltio C1 - 6NO2 or CN; each of r6a and R6B is independently H or alkyl c1-3; each of R7 and R8 is H, alkyl Regardless, C1 - 6Aryl or aryl substituted with 1 to 3 substituents selected between group consisting of F, CL, BR, I, o, c1-c6 alkyl, alkoxy alkyl C1 - Halo - C1 - 6, 6, 6 Alquiltio C1 -, phenyl, NO2,NH2 or CN; and Pharmaceutical salts thereof. Are also proposed