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Sulfonyl derivatives substituted by heterocycle - etanodionanilina substituted by Heterocycles, Pharmaceutical composition containing them and their use for a drug lamanufactura
Sulfonyl derivatives substituted by heterocycle - etanodionanilina substituted by Heterocycles, Pharmaceutical composition containing them and their use for a drug lamanufactura
Sulfonyl derivatives substituted by heterocycle substituted by heterocycle - etanodionanilina having the formula (1) wherein R1 and R2 together with elnitrogeno are United to form a Ring of 47 members; R3 and R4 together with nitrogen are United to form a Ring of 4 to 7 members; R5 isformula (2) or alkyl C1 - 6Preferably Methyl; Pharmaceutical composition containing them and their use for the manufacture of a drug to block laapoptosis excessive or inappropriateTo treat diseases or Disorders associated with excessive activity of il-1beta odisminuir Convertase and / or to block the production of il-1beta and / or TNF.
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