Acetidinalquilicos Derivatives of N - substituted Heterocycles with nitrogen or pharmaceutically acceptable salts of the same, a procedure paraprepararlos,Pharmaceutical compositions containing such Derivatives, use of Salts and compositions and compounds useful as Intermediates

摘要

Acetidinalkyl derivatives of heterocycles with N-substituted nitrogen of formula (I) and pharmaceutically acceptable salts thereof, wherein C3-C7 cycloalkyl Res; aryl or C1-C4 alkyl, optionally substituted with fluorine, - COOH, - COO C1-C4 alkyl, C3-C7 cycloalkyl, adamantyl, aryl or het1, the C3-C7 cycloalkyl being optionally substituted with 1 or 2 substituents each independently selected from C1-C4 alkyl, C3-C7 cycloalkyl, C1-C4 alkoxy, hydroxy, fluorine, C1-C4 fluoroalkyl and CC1-C4 fluoroalkoxy; A is CO or SO2; R1 is phenyl, benzyl, naphthyl, thienyl,Benzotienilo or indolilo, each replaced by one or two independently selected substitutes from c1-c4alcixi C1-C4, halogenated and trifluoromethyl tar, r2e-co2h, conr3r4, conr5cycloquilo C3-C7, N3 (alkane C2-C3),-Nr3r4-nr5conr5r6 (cycloquilo c3-c7-c1-c4 tar) r5n -,(cycloquilo c3-c7quilo C1-C4) 2n -, nr5coff3, - nr5so2cf3 -, NR5 (SO2 rental C1-C4), nr5so2nr5r6, - NR5 (aril SO2),-N (ARL) (SO2 C1-C4 asphalt);5. Or5-o (cycloquilo C3-C7), so2nr5r6, het1 a (IX);X is C1-C4 tar; X1 is a direct link or tar of C1-C6; m is O, 1 or 2. Nitrogen dioxide and salt marsh are competitive. The invention also relates to the procedures for preparing them, pharmaceutical ingredients including them, the use of these derivatives, salts and compounds, and delicate combinations in the middle, etc.