Piperazine derivatives and piperazinona substituted Heterocycles useful as Tachykinin Receptor Antagonists, Pharmaceutical composition that includes one of these Derivatives.Use of these compounds in the preparation of compositions and Process for the preparation of derivatives

摘要

The derivative of the present invention conforms to formula (I),Where G is - ch2-o-c (o) -;AR1 is a kind of radical substance selected from phenyl, substituted phenyl, nafilo, substituted naftio, R1 is hydrogen, a kind of hot acrylonitrile, - (CH2) qar2 or CH 2C (o) ar2; q is an integer from 1 to 4, ar2 is nontoxic phenyl, substituted phenyl or isobutylene; R2 is hydrogen, C1-C4 tar or Cho; R3 refers to hydrogen or radical substance selected from phenyl, phenyl substitute, northwest non-n-butyl or its stereoisomer or pharmaceutically acceptable salt. An intermediate is also introduced for plasma repair of these derivatives, which conforms to the formula of (2), wherein R1, R3 and R2 are intermediates defined above, and R5 is selected from nitrogen,Preparation procedure for c1-c (or) or7 hydrogen (or) C1-C4 hydrocarbon groups and these derivatives between C1-C4 and R6. The derivatives of piperazina and piperazina are useful as symbionts of taquikininas receptors for the treatment of diseases and conditions controlled by taquikininas, including asthma, cough and bronchitis. These derivatives are included in pharmaceutical ingredients and have acceptable pharmaceutical ingredients.