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A polymorphic form of Salt of Maleic acid derivative of tiazolidina - 2,4 Dione, a Pharmaceutical Composition and the use thereof for the manufacture of a medicament

机译:噻唑烷的马来酸衍生物盐的多晶型形式-2,4 Dione,药物组合物及其在制备药物中的用途

摘要

A polymorphic form of Maleic acid salt of 5 - [4 - [2 - (n-methyl-n - (2-pyridyl) amino) ethoxy] benzyl] thiazolidine-2,4-dione, that: (i) provides a espectroinfrarrojo containing Peaks to 1360, 1326,1241, 714 and 669 cm-1; and / or (ii) provides unespec tro Raman Peaks which contains 1.581, 768 670, 271,,,And 226 - and / or (iii) provides a Spectrum of Solid State Nuclear magnetic resonance Chemical shifts substantially containing Peaks are as in table I and / or (iv) by proProvides an x-ray diffraction Pattern From Dust (XRPD) that substantially contains Peaks set in Table II; a method for preparing Said CompoundA Pharmaceutical composition containing Said compound and use of said compound in to put it, the manufacture of a drug in Medicine.
机译:5- [4- [2-[-(n-甲基-n-(2-吡啶基)氨基)乙氧基]苄基]苄基]噻唑烷-2,4-二酮的顺丁烯二酸盐的多晶型形式,其中:(i)提供一种鞘氨醇包含1360、1326、1241、714和669 cm-1的峰;和/或(ii)提供包含1.581、768 670、271,和226的未指定的拉曼峰,并且//或(iii)提供固态核磁共振波谱基本包含峰的化学位移如下表I和 /或(iv)由pro提供基本包含表II中设置的峰的X射线尘埃衍射图样(XRPD);制备所述化合物的方法一种包含所述化合物的药物组合物,以及将所述化合物放入其中的用途,以制备药物。

著录项

  • 公开/公告号AR023564A1

    专利类型

  • 公开/公告日2002-09-04

    原文格式PDF

  • 申请/专利权人 SMITHKLINE BEECHAM PLC;

    申请/专利号AR2000P101865

  • 发明设计人

    申请日2000-04-19

  • 分类号C07D417/12;A61K31/44;A61K31/425;A61K31/427;A61P3/10;

  • 国家 AR

  • 入库时间 2022-08-22 00:46:24

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