首页> 外国专利> A polymorphic form of a Derivative of Maleic acid tiazolidin Dione - 2, 4, a Pharmaceutical Composition and the use of said Polymorph to put it, the manufacture of a medicament

A polymorphic form of a Derivative of Maleic acid tiazolidin Dione - 2, 4, a Pharmaceutical Composition and the use of said Polymorph to put it, the manufacture of a medicament

机译:马来酸噻唑烷二酮二酮衍生物的多晶型物-2,4,药物组合物以及所述多晶型物的使用,药物的制造

摘要

A polymorphic form of Maleic acid salt of 5 - [4 - [2 - (n-methyl-n - (2-pyridyl) amino) ethoxy] benzyl] thiazolidine-2,4-dione (Polymorph)Caracterizadoporque provides (i) an infrared Spectrum contains Peaks to 1763, 912, 856 tonnes 709 cm-1, and / or (ii) a Raman Spectrum contains Peaks to 1762, 1.284, 912y 888 cm - 1, and / or (iii) a Spectrum of nuclear magnetic resonance in Solid State 13C containing Peaks to 111.0, 113.6 129.1, 130.9 131.8 119.8,,,, 134,7138,7, 146.5 152.7 157.5, 169,,,5 171.0 178.7 ppm; and / or (iv) an x-ray diffraction Pattern through the Dust (XRPD) that gives reticularescalculadas distances to 5.87, 5.30, 4.69, 4.09, 3.88, 3.61, 3.53 and 346 angstroms; a procedure for preparing such a Compound, a Pharmaceutical composition containing Said compound and use of said compound in Medicine.
机译:5- [4- [2-[-(n-甲基-n-(2-吡啶基)氨基)乙氧基]苄基]马来酸盐的多晶型形式噻唑烷-2,4-二酮(多晶型)Caracterizadoporque提供(i)红外光谱的峰值为1763、912、856吨709 cm-1和/或(ii)拉曼光谱的峰值为1762、1.284、912y 888 cm-1和/或(iii)核光谱在固态13C中的磁共振,其峰分别为111.0、113.6 129.1、130.9 131.8 119.8 、、、 134,7138,7、146.5 152.7 157.5、169,,5 171.0 178.7 ppm;和/或(iv)通过尘埃的X射线衍射图(XRPD),其网状结石的距离分别为5.87、5.30、4.69、4.09、3.88、3.61、3.53和346埃;制备此类化合物的方法,含有所述化合物的药物组合物以及所述化合物在医学中的用途。

著录项

  • 公开/公告号AR023561A1

    专利类型

  • 公开/公告日2002-09-04

    原文格式PDF

  • 申请/专利号AR2000P101862

  • 发明设计人

    申请日2000-04-19

  • 分类号C07D417/12;A61K31/44;A61K31/425;A61P3/10;

  • 国家 AR

  • 入库时间 2022-08-22 00:46:24

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