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Compound, process for preparing the compound, composition, use of a compound, and method of treating allergic diseases including bronchial asthma, rhinitis, conjunctivitis, dematosis and urticaria

机译:化合物,该化合物的制备方法,组合物,化合物的用途以及治疗过敏性疾病的方法,包括支气管哮喘,鼻炎,结膜炎,脱皮和荨麻疹

摘要

"COMPOUND, PROCESS TO PREPARE COMPOUND, COMPOSITION, USE OF A COMPOUND, AND METHOD OF TREATING ALLERGIC DISEASES INCLUDING BRONCHIC ASTHMA, RHINITIS, CONJUNTIVITIS, DEMATOSIS AND URTICARIES". Indolylpiperidine compounds of formula (I) in which: A ^1 ^ represents an alkylene, alkyleneoxy, alkylenethio, alkanoyl or hydroxyalkylene group; A 2 represents a single bond, an alkylene group or an alkenylene group; W represents a single bond or a phenylene or furanylene group that is substituted or unsubstituted by one or more halogen atoms, alkoxy groups and / or alkyl groups; R ^ 1 ^ represents a hydrogen atom or an alkyl, alkenyl, alkynyl, alkoxyalkyl, alkenyloxyalkyl, alkynyloxyalkyl alkoxyalkoxyalkyl group, phenylalkyl group in which the phenyl ring is substituted or unsubstituted by one or more halogen atoms or alkyl groups, alkoxy or arylalkoxy or a cycloalkylalkyl group in which cycloalkyl group is substituted or unsubstituted by one or more halogen atoms, alkyl groups or alkoxy groups; R ^ 2 ^ represents a hydrogen or halogen atom or an alkyl or alkoxy group; and R3 represents a carboxyl group or a tetrazolyl group; and their pharmaceutically acceptable salts, process for their preparation and medicinal use.
机译:“化合物,化合物的制备过程,组成,化合物的使用以及治疗过敏性疾病的方法,包括支气管哮喘,鼻炎,结膜炎,脱氢症和尿毒症”。式(I)的吲哚基哌啶化合物,其中:A ^ 1 ^代表亚烷基,亚烷基氧基,亚烷基硫基,烷酰基或羟基亚烷基; A 2表示单键,亚烷基或亚烯基; W表示单键或被一个或多个卤素原子,烷氧基和/或烷基取代或未取代的亚苯基或呋喃基; R ^ 1 ^代表氢原子或烷基,烯基,炔基,烷氧基烷基,烯基氧基烷基,炔基氧基烷基烷氧基烷氧基烷基,其中苯环被一个或多个卤素原子或烷基取代或未被取代的苯基烷基,烷氧基或芳基烷氧基或环烷基烷基,其中环烷基被一个或多个卤素原子,烷基或烷氧基取代或未被取代; R ^ 2 ^代表氢或卤素原子或烷基或烷氧基; R 3表示羧基或四唑基。及其药学上可接受的盐,其制备方法和药用用途。

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