Benzazole derivatives, use of benzazole derivatives, method to inhibit the expression and / or activity of jnk, method for treating morbid conditions mediated by jnk, pharmaceutical composition containing a benzazole derivative and process for the preparation of a benzazole derivative

摘要

"BENZAZOLE DERIVATIVES, USE OF BENZAZOLE DERIVATIVES, METHOD TO INHIBIT JNK EXPRESSION AND / OR ACTIVITY, METHOD FOR TREATMENT OF MORBID STATES MEASURED BY JNK, PHARMACEUTICAL COMPOSITION OF A HAZARDOUS DERIVATION OF BENZOZ ". The present invention relates to benzazole derivatives according to formula (I) in which x is o, s, or nr ^ 0 ^ with r ^ 0 ^ being h or a c ~ 1 ~ -c ~ 6 ~ -alkyl unsubstituted or substituted, eg it is an unsubstituted or substituted pyrimidinyl group, notably for use as pharmaceutically active compounds, as well as pharmaceutical formulations containing such benzazole derivatives, such benzazole derivatives are efficient modulators of the jnk pathway, and are in particular efficient inhibitors and selective jnk2 and / or 3.