SOLID FORM OF CELLO-COXYB THAT HAS IMPROVED BIO ACCESSIBILITY

摘要

Developed a selective drug celecoxib, inhibiting cyclooxygenase-2, in amorphous form. A celecoxib drug substance has also been developed, in which celecoxib is present, at least in detectable amounts, in the form of amorphous celecoxib. A composite inhibiting crystallization of celecoxib has also been developed, including particles of an amorphous celecoxib or celecoxib drug substance according to this invention in association with one or more crystallization inhibitors, for example polymers. Also developed a pharmaceutical composition comprising such a composite, inhibiting the crystallization of celecoxib, and one or more formative substances. Methods have also been developed for producing amorphous celecoxib, a celecoxib drug substance in accordance with this invention, a celecoxib crystallization inhibitory composite in accordance with this invention, and a pharmaceutical composition in accordance with this invention. A method has also been developed for treating a medical condition or disorder in a subject to whom treatment with cyclooxygenase-2 inhibitor is indicated, comprising administering, for example, orally a composition according to the invention in a therapeutically effective amount. The international application was published along with an international search report.