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CHLOROPHYLL AND BACTERIO CHLOROPHYLL DERIVATIVES, METHOD FOR PRODUCING THEM AND DIAGNOSTIC AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF
CHLOROPHYLL AND BACTERIO CHLOROPHYLL DERIVATIVES, METHOD FOR PRODUCING THEM AND DIAGNOSTIC AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF
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机译:叶绿素和细菌叶绿素衍生物,其制备方法以及包含其的诊断和药物组合物
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摘要
FIELD OF THE INVENTION The present invention relates to novel chlorophyll (Chl) and bacteriochlorophyll (Bch1) derivatives, their preparation and their use as formulations in the use of fluorescent detection and traceability techniques and cancer photodynamic therapy. According to the method of the invention, conjugates of chlorophyll (Chl) and bacteriochlorophyll (Bch1) are produced in which the conjugate molecule is attached to the 17-propionyl-Chl or Bch1 group. The conjugates according to the invention accumulate in tumor cells and tissues and can be used for diagnosing tumors and as a photosensitizer for afotodynamic therapy (PTD). ŕ
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