HALOVIR, AN ANTIVIRAL MARINE NATURAL PRODUCT, DERIVATIVES THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

摘要

The present invention provides a compound having the structure (I) wherein R?la and R1b¿ are independently selected from the group consisting of -H, alkyl, lower-alkyl, substituted alkyl and substituted lower-alkyl; R?2a and R2b¿ are independently selected from the group consisting of -H, lower-alkyl, and substituted lower-alkyl; R3 is -H, lower-alkyl, substituted lower-alkyl and where R?3 and R4¿ are attached together by a lower-alkyl or a substituted lower-alkyl moiety; R4 is -H, lower-alkyl, substituted lower-alkyl and where R?3 and R4¿ are attached together form a lower-alkyl or substituted lower-alkyl bridge; R?5, R7, R9 and R11¿ are independently selected from the group consisting of -H, lower-alkyl, and substituted lower-alkyl; R6 is -H, lower-alkyl and substituted lower-alkyl; R8 is -H, lower-alkyl and substituted lower-alkyl; R10 is -H, lower-alkyl and substituted lower-alkyl; R12 is -H, lower-alkyl and substituted lower-alkyl; and A is -C(O)-R13, wherein R13 is -H, -OH, alkyl, lower-alkyl, substituted lower-alkyl or -O(lower-alkyl); -CH¿2-OR?14 wherein R14 is -H, -C(O)CH¿3?, alkyl, lower-alkyl or substituted lower-alkyl; or -CH2-NR?15R16¿, where R?15 and R16¿ are independently selected from -H, lower-alkyl, alkyl, substituted lower-alkyl or substituted alkyl; a pharmaceutically acceptable salt or derivatives thereof, useful for preventing or treating viral and microbial infections.