Crystalline polymorph of (-)-4-4-4-4-(2R-cis)-5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl-methoxyphenyl-1-piperazinylphenyl-2,4-dihydro-2-(S)-1-ethyl-2(S)-hydroxylpropyl-3H-1,2,4-triazol-3-one and its use as a fungicide

摘要

A crystalline polymorph of (-)-4-[4-[4-[4-[[(2R-cis)-5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4 -triazol-1-ylmethyl)furan-3-yl]-methoxy]phenyl]-1-piperazinyl]phenyl-2 ,4-dihydro-2-[(S)-1-ethyl-2(S)-hydroxylpropyl]-3H-1,2,4-triazol-3-one (refer to the formula shown). The described polymorph has an x-ray powder diffraction pattern expressed in terms of "d" spacing and relative intensities ("RI") (refer to the table shown). The polymorph has a lower impurity content and more consistent product quality i.e., more consistent physical characteristics including more consistent colour, rate of dissolution and ease of handling; as well as a longer term stability compared to its amorphous form. The polymorphs are useful for the treatment and prevention of fungal infections in mammals.