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Spray coated powder composition formed from seed particles between 10-100 micrometres coated with an aqueous pharmaceutical composition
Spray coated powder composition formed from seed particles between 10-100 micrometres coated with an aqueous pharmaceutical composition
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机译:由10-100微米之间的种子颗粒形成的喷雾包衣粉末组合物,被水性药物组合物包被
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摘要
Described are spray-coated pharmaceutical powder compositions for transdermal administration using a needless syringe comprising seed particles coated with a pharmaceutical composition. The coated seed particles have an average size of between 10 and 100 micrometres and an envelope density ranging from 0.1 to 25g/cm2. A method for preparing the spray-coated powder is disclosed. The method comprising the steps of: (a) suspending the seed particles in a reaction chamber using a heated airflow; (b) atomising an aqueous pharmaceutical composition into a spray and introducing the spray into the reaction chamber; (c) allowing the spray to spread over the surface of the suspended seed particles so they are coated with a film; and (d) drying the coated seed particles.
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机译:描述了使用不需要的注射器的用于经皮施用的喷雾包衣的药物粉末组合物,该注射器包括用药物组合物包被的种子颗粒。包衣的种子颗粒的平均尺寸为10至100微米,包膜密度为0.1至25g / cm 2。公开了一种制备喷涂粉末的方法。该方法包括以下步骤:(a)使用加热的气流将种子颗粒悬浮在反应室中; (b)将水性药物组合物雾化成喷雾剂并将喷雾剂引入反应室中; (c)使喷雾剂散布在悬浮的种子颗粒的表面上,使它们被薄膜覆盖; (d)干燥包衣的种子颗粒。
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