Azepino 4,5-b derivatives as ligands substituted indole receptor serotonin 5HT

摘要

Refers to azepino derivatives [4,5-b] indole substituted formula I where R1 is H, alkyl C8 hidrocarbileno C1 C1, C8 - AR - C8 alkyl; R2 is C1, oh; R3 is H, alkyl C1 C8, AR, Het, r7c (= o),R7oc (= o), r5r6nc, RC (= o) - hidrocarbileno C1 C8 - C (= o), among others, R5 and R6 are h, alkyl C8 alquenilo C1 - C2, C8, alquinilo C2 C8 or next to n form pirrolidino, piperidino, morpholino; R4 is arC1 to C8 alkyl alkoxy -, ring - C1, C8, Het, Halo, Oh, nrarb, R7S; R7 is H, alkyl C8 alquenilo C1 - C2, C8, haloalquilo C1 C8; rarb is H, alkyl C1 C8, AR, so2ar is 0; P - Q is 0 - 4; 8; RC is het, arR7co2, r7c (= OR), ar is aryl, heteroaryl; with the condition that R IS h, alkyl C8 fenilhidrocarbileno C1, C1 C8; Q is 0, then p is 3 - 4, p is 1 - 2; R4 is different from C1 C8 alkyl, haloC1 C8 alkoxy -, among other conditions.Preferred compounds are 10 - (4-ethoxyphenyl) - 1 - hexahidroazepino [4,5-b] indole; 10 - (2 - butoxifenil hexahidroazepino) - 1 - [4,5-b] indole; 10 - [2 - (cyclohexyloxy) phenyl) - 1,2,3,4,5,6 - hexahidroazepino [4,5-b] indole; 10 - (2 - (ciclobutiloxifenil hexahidroazepino) - 1 - [4,5-b] indole.The compounds are serotonin 5HT receptor ligands and may be useful for the treatment of anxiety, depression, Epilepsy, migrana related disease, obesity, stress,Withdrawal of Drug Abuse