SIGNAL SEQUENCES FOR PREPARING LEU-HIRUDIN BY SECRETION BY E.COLI INTO THE CULTURE MEDIUM

摘要

Abstract:The present invention relates to a hirudin precursor comprising a signal sequence and the sequence of Leu-hirudin, to its preparation and use, and to a process for finding signal sequences for secretory expression of any desired proteins in E. coli and process for the secretory expression of any desired proteins in E. coli.