Bioadhesive composition not containing enzymatic oxidizing agent or chemical cross-linking agent comprises bioadhesive polyphenolic protein, a polymer, fine filaments, optionally a non-enzymatic oxidizing agent, and a filler protein

摘要

Bioadhesive composition (I) comprises a bioadhesive polyphenolic protein comprising 30-3000 amino acids, comprises tandemly linked peptide repeats of 3-15 amino acid residues; (ii) a polymer comprising carbohydrates; (iii) fine filaments; (iv) optionally a non-enzymatic oxidizing agent; and (v) a filler protein. (I) does not contain an enzymatic oxidizing agent or chemical cross-linking agent. Bioadhesive composition comprises: (i) a bioadhesive polyphenolic protein derived from a byssus-forming mussel comprising 30-3000 amino acids consisting tandemly linked peptide repeats of 3-15 amino acid residues, at least 5% and preferably 6-25% are at least 5 % and preferably 6-25 % has 3,4 dihydroxy-L-phenylalanine (DOPA); (ii) a polymer comprising carbohydrate groups such as heparin, chondroitin sulfate, chitosan and hyaluronan; (iii) fine filaments; (iv) optionally a non-enzymatic oxidizing agent such as hydrogen peroxide, nitroprusside ions or periodate ions; and (v) a filler protein, such as collagen, albumin, casein, elastin, fibronectin or fibrin. (I) does not contain an enzymatic oxidizing agent or chemical cross-linking agent. An Independent claim is also included for: (1) a bioadhesive composition (II) with a composition as (I) which does not comprise any enzymatic oxidizing agent or chemical cross-linking agent, for medical use; and (2) a composition (III) comprising (i) and (ii), and does not comprise any enzymatic oxidizing agent or chemical cross-linking agent.