New bioadhesive composition comprising a bioadhesive polyphenolic protein, a polymer comprising carbohydrate groups, pharmaceutically acceptable fine filaments and uses thereof

摘要

A non-irritating, non-allergenic and non-toxic bioadhesive composition can be obtained by providing a bioadhesive composition comprising a) a polyphenolic protein derived from byssus-forming mussels, b) a polymer comprising carbohydrate groups, and c) pharmaceutically acceptable fine filaments. The bioadhesive composition does not contain any enzyme or chemical cross-linking agent. Optionally, the composition may contain an oxidising agent and/or a filler protein. Preferably, the composition is provided as a kit of at least two parts, namely the polyphenolic protein and the polymer comprising carbohydrate groups, respectively. The composition is especially suitable as an adhesive in ophthalmic therapy.