ADENOVIRUS INCOMPLETE RECOMBINANTS EXPRESSING CITOCINES FOR ANTITUMORAL TREATMENT.

摘要

THE INVENTION CONCERNS A RECOMBINANT NUCLEIC ACID USED FOR THE PRODUCTION OF A DEFECTIVE ADENOVIRUS THAT CONTAINS A CODING INSERT FOR A CYTOKIN UNDER THE CONTROL OF A PROMOTER IN THE BREAST OF THE GENOMIC SEQUENCE OF THE RECOMBINING ADENOVIRUS. THIS RECOMBINANT ADENOVIRUS IS USABLE FOR THE PREPARATION OF ANTITUMOR DRUGS IN A DIRECTLY INJECTABLE FORM IN THE TUMOR OF THE GUEST.