RETROVIRAL VECTORS WITH FOREIGN-SEQUENCE INSERTION BETWEEN RETROVIRAL PRIMER BINDING SITE AND RETROVIRAL SPLICE DONOR

摘要

The subject of the invention is retroviral gene transfervectors in which foreign sequences are introduced betweenthe retroviral primer binding site (PBS) and theretroviral splice donor (SD). The efficiency of geneexpression is improved by this modification, and thevectors are characterized by an increased reliabilityduring use.